Bifunctional Single‐Atom Iron Cocatalysts Enable an Efficient Photoelectrochemical Fuel Cell for Sensitive Biosensing

An auto-biotinylated bifunctional protein nanowire for ultra-sensitive molecular biosensing.

In order to obtain an ultra-sensitive molecular biosensor, we designed an auto-biotinylated bifunctional protein nanowire (bFPNw) based on the self-assembly of a yeast amyloid protein, Sup35, to which protein G and a biotin acceptor peptide (BAP) were genetically fused. These auto-biotinylated bFPNws can transfer hundreds of commercially available diagnostic enzymes to an antigen-antibody compl...

A localized surface plasmon resonance-enhanced photoelectrochemical biosensing strategy for highly sensitive and scatheless cell assay under red light excitation.

In this work, a novel photoelectrochemical biosensing strategy was designed for cell assay under 630 nm (red light) excitation. WS2/Au NP nanocomposites were prepared as a photoelectrochemical biosensing substrate. The localized surface plasmon resonance effect of Au NPs tremendously improved the photoelectric conversion efficiency and enhanced the detection sensitivity.

Biosensing: Enhanced Charge Collection in MOF‐525–PEDOT Nanotube Composites Enable Highly Sensitive Biosensing (Adv. Sci. 11/2017)

Enhanced Charge Collection in MOF‐525–PEDOT Nanotube Composites Enable Highly Sensitive Biosensing

With the aim of a reliable biosensing exhibiting enhanced sensitivity and selectivity, this study demonstrates a dopamine (DA) sensor composed of conductive poly(3,4-ethylenedioxythiophene) nanotubes (PEDOT NTs) conformally coated with porphyrin-based metal-organic framework nanocrystals (MOF-525). The MOF-525 serves as an electrocatalytic surface, while the PEDOT NTs act as a charge collector ...

pH-Sensitive, N-ethoxybenzylimidazole (NEBI) bifunctional crosslinkers enable triggered release of therapeutics from drug delivery carriers.

This paper presents a pH-sensitive bifunctional crosslinker that enables facile conjugation of small molecule therapeutics to macromolecular carriers for use in drug delivery systems. This N-ethoxybenzylimidazole (NEBI) bifunctional crosslinker was designed to exploit mildly acidic, subcellular environments to trigger the release of therapeutics upon internalization in cells. We demonstrate tha...